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Senior Research Associate II, Medicinal Chemistry

Santee, California
Job Type
23 Sep 2022

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Job Description

About the role:

We are seeking a creative and highly motivated scientist to apply innovative synthetic organic and medicinal chemistry principles and techniques toward the discovery of medicines in the Neuroscience Drug Discovery Unit. The successful applicant will perform laboratory-based synthesis, purification, and characterization activities for bioactive molecules. Strong laboratory-based focus, experimental excellence and well-developed communication and collaboration skills are required for this position.

Join Takeda as a Sr. Research Associate II, Medicinal Chemis in our Neuroscience Chemistry team, based in San Diego, CA.

How you will contribute:


  • Independently synthesize, purify, and characterize biologically active molecules with suitable drug-like properties with efficiency, accuracy, and attention to detail
  • Understand, analyze, and interpret structure-activity relationships based on in vitro biological data, and clearly communicate SAR to chemistry team members.
  • Designs synthetic targets for lead discovery and optimization to address issues of target potency, selectivity, animal pharmacokinetics, toxicity, physical property, and in vivo efficacy
  • Acts as member of a multidisciplinary drug discovery project team, assisting with synthesis and scale-up activities for high priority lead compounds.
  • Maintains a current understanding of the synthetic literature and methodology, as well as the scientific literature related to a specific drug discovery project.
  • Creates relevant intellectual property for the company and contributes to patent authorship.
  • Keep a well-organized Electronic Lab Notebook


  • Basic wet lab skills and experience, including synthetic chemistry reaction set-up, monitoring, and purification.
  • Experience with analytical and purification methods such as NMR, LCMS, HPLC, and silica gel chromatography
  • Practical experience in Medicinal Chemistry in either academic or industrial setting is preferred.
  • Excellent communication skills, both written and oral
  • Demonstrated ability to solve scientific problems creatively, effectively, and independently

Minimum Requirements/Qualifications:

  • Bachelor's degree in a scientific discipline (or equivalent) with 4+ years of experience
  • Master's degree in a scientific discipline (or equivalent) with 2+ years of experience


  • Exposure to hazardous/toxic/dangerous chemicals and biohazards.
  • Prolonged standing in the laboratory to perform synthetic organic chemistry.
  • Manual dexterity required to operate standard laboratory equipment (ie LCMS, NMR, etc.).
  • Carrying, handling, and reaching for objects.

What Takeda can offer you:

  • Comprehensive Healthcare: Medical, Dental, and Vision
  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs and company match of charitable contributions
  • Family Planning Support
  • Flexible Work Paths
  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time
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  • Job Reference: 719466676-2
  • Date Posted: 23 September 2022
  • Recruiter: Takeda Pharmaceutical
  • Location: Santee, California
  • Salary: On Application
  • Sector: Science & Technology
  • Job Type: Permanent